Dark Light
Personalized molecular glue complexes with desired properties

Technology tamfitronics

  • Study Highlight
  • Published:

Protein engineering

Nature Biotechnology volume42,web page 571 (2024)Cite this article

Degron tags can feature off swiftly and temporally controlled degradation of proteins the utilization of tiny molecules identified as molecular glues. These molecular glues induce or stabilize protein interactions between a aim protein and a ubiquitin ligase. As examine instruments, molecular glue complexes are restricted by the powerful size of degron tags, which prevents integration in endogenous protein-coding genes. In a ogle printed in ScienceMercer et al. apply a gentle evolution solution to generate molecular glue complexes with high affinities and smaller size, obtaining a compact degron that triggers protein degradation and not using a detectable off-aim results.

Unusual work developed an optimized molecular glue, PT-179, that binds cereblon to feature off protein degradation. Unlike its predecessors, PT-179 does now not degrade off-aim proteins, making it an supreme starting up block to get molecular glue complexes with improved properties.

Right here’s a preview of subscription thunder material, get entry to via your institution

Rating steady of entry to alternatives

Rating steady of entry to Nature and 54 assorted Nature Portfolio journals

Rating Nature+, our easiest-price online-get entry to subscription

24,Ninety 9 /30days

assassinate any time

Subscribe to this journal

Gain 12 print points and online get entry to

214,86 per year

easiest 17,91 per boom

Buy this article

  • Aquire on Springer Hyperlink
  • Instantaneous get entry to to fleshy article PDF

Costs would per chance be field to local taxes which would be calculated at some stage in checkout

Creator info

Authors and Affiliations

  1. Nature Biotechnology https://www.nature.com/nbt/

    Iris Marchal

Corresponding creator

Correspondence to Iris Marchal.

About this article

Technology tamfitronics Take a look at for updates. Take a look at forex and authenticity via CrossMark

Cite this article

Marchal, I. Personalized molecular glue complexes with desired properties. Nat Biotechnol 42571 (2024). https://doi.org/10.1038/s41587-024-02212-4

Gain citation

  • Published:

  • Declare Date:

  • DOI: https://doi.org/10.1038/s41587-024-02212-4


Discover more from Tamfitronics

Subscribe now to keep reading and get access to the full archive.

Continue reading