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Decrypting the molecular foundation of cell drug phenotypes by dose-resolved expression proteomics

Decrypting the molecular foundation of cell drug phenotypes by dose-resolved expression proteomics

Technology tamfitronics Predominant Most tablets act on proteins1,2 and it has been known since the times of Paracelsus that tablets exert their effects in a dose-dependent model. The molecular processes main to a drug-prompted replace in cell phenotype can even be roughly divided into (1) aim binding, (2) pathway engagement and (3) cell reprogramming to […]

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Personalized molecular glue complexes with desired properties

Personalized molecular glue complexes with desired properties

Technology tamfitronics Study Highlight Published: 17 April 2024 Protein engineering Iris Marchal1 Nature Biotechnology volume42,web page 571 (2024)Cite this article 31 Accesses 1 Altmetric Metrics tiny print Degron tags can feature off swiftly and temporally controlled degradation of proteins the utilization of tiny molecules identified as molecular glues. These molecular glues induce or stabilize protein […]

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