Durable epigenetic silencing with a TALE-based editor

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Epigenetics
Nature Biotechnology (2025)Cite this article
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Transient expression of a transcription activator-like effector (TALE)-based epigenetic editor demonstrates durable therapeutic silencing in non-human primates.
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L.S.Q. is a founder of Epicrispr Biotechnologies and scientific advisor to the Laboratory of Genomic Research.
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Wachsmann, T.L.A., Qi, L.S. Durable epigenetic silencing with a TALE-based editor. Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02871-x
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DOI: https://doi.org/10.1038/s41587-025-02871-x