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Durable epigenetic silencing with a TALE-based editor

Durable epigenetic silencing with a TALE-based editor
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Epigenetics

Nature Biotechnology (2025)Cite this article

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Transient expression of a transcription activator-like effector (TALE)-based epigenetic editor demonstrates durable therapeutic silencing in non-human primates.

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Fig. 1: Development of TALE-based epigenetic regulators (EpiRegs) for in vivo silencing of PCSK9 in mice and monkeys.

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Author information

Authors and Affiliations

  1. Department of Bioengineering, Stanford University, Stanford, CA, USA

    Tassilo L. A. Wachsmann & Lei S. Qi

  2. Sarafan Chem-H, Stanford University, Stanford, Ca, USA

    Lei S. Qi

  3. Chan Zuckerberg Biohub – San Francisco, San Francisco, CA, USA

    Lei S. Qi

Authors

  1. Tassilo La Wachsmann
  2. Lei S. Qi

Corresponding author

Correspondence to Lei S. Qi.

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Competing interests

L.S.Q. is a founder of Epicrispr Biotechnologies and scientific advisor to the Laboratory of Genomic Research.

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Cite this article

Wachsmann, T.L.A., Qi, L.S. Durable epigenetic silencing with a TALE-based editor. Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02871-x

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  • DOI: https://doi.org/10.1038/s41587-025-02871-x

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