Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR–Cas9 ribonucleoprotein
17 Oct
Science & Technology

Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR–Cas9 ribonucleoprotein

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Technology tamfitronics MainClustered regularly interspaced short palindromic repeats (CRISPR)–Cas9-based genome editing1,2,3 has the potential to provide wide-ranging treatments for genetic diseases4,5,6 if safe and effective methods for delivering CRISPR-based therapeutics can be developed7,8. Although viral delivery of CRISPR genome editors is the most widely used method for in vivo cell editing9,10,11, viral vectors can be immunogenic, carry the risk of vector genome integration and can induce off-target DNA damage because of continuous genome editor expression12. Alternative nonviral strategies for delivering CRISPR editors could address these limitations if issues of efficacy and toxicity can be overcome.Lipid nanoparticle (LNP)–mRNA complexes are nonvirally derived vehicles for in vivo delivery that have been remarkably successful at genome editing in...
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Google Signs Agreement for 500 MW of Nuclear Power From Kairos Power by 2035
17 Oct
Science & Technology

Google Signs Agreement for 500 MW of Nuclear Power From Kairos Power by 2035

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Technology tamfitronics Home » Artificial intelligence » Google Signs Agreement for 500 MW of Nuclear Power From Kairos Power by 2035Google has a corporate agreement to buy energy (starting with 7 small nuclear reactors) from Kairos Power. Kairos Power FHR (KP-FHR) is a novel advanced reactor technology that leverages TRISO fuel in pebble form combined with a low-pressure fluoride salt coolant. The technology uses an efficient and flexible steam cycle to convert heat from fission into electricity and to complement renewable energy sources. It is high temperature pebble bed power. China already has a 210 MW pebble bed reactor providing commercial power.Kairos Power and Google have signed a Master Plant Development Agreement, creating a path to deploy a U.S. fleet of advanced nuclear power projects totaling 500 MW by 2035.Kairos Power will develop, construct, and...
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