Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues
Technology tamfitronics MainChromatin organization plays a crucial role in both embryonic development1,2 and the progression of various diseases3,4. During development, the chromatin structure influences which genes are turned on or off by the distal regulatory elements5,6,7,8. Abnormal chromatin organization can lead to aberrant gene expression or silencing, contributing to cancer development and metastasis4. Indeed, components of the nuclear machinery that regulates chromatin organization are among the most frequently mutated genes in human cancers9,10,11,12. Thus, a comprehensive analysis of the chromatin organization is crucial for understanding the gene regulatory programs involved in both normal development and disease pathogenesis.Analyzing chromatin organization in primary tissues and tumor biopsies presents unique challenges owing to the complexity of chromatin dynamics...
