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Technology tamfitronics MainRaman spectroscopy has been widely applied in chemical, material and biomedical sciences by detecting the inelastic light scattering of small molecules1. Complementary to fluorescence or other imaging modalities, Raman spectroscopy for bioimaging measures chemical-bond-specific vibrational transitions that unravels chemical information of molecules such as nucleic acids, proteins and lipids, related to the genotype, phenotype and physiological state of the cell2. The ultranarrow spectral peak width of Raman signal offers the opportunity to detect multiple tags simultaneously using a single laser excitation, capable of multiplexed imaging3. Moreover, owing to the extremely short lifetimes of Raman scattering, Raman signals are stable against photobleaching or quenching, which is ideal for imaging studies of prolonged duration4.Despite these...