Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology
Science & Technology

Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology

Technology tamfitronics Chandrashekhar Madasu, in cyan Liao https://orcid.org/0000-0002-7198-2182, Sydney E. Parks, Kiran L. Sharma https://orcid.org/0000-0002-1988-389X, Kurt M. Drill https://orcid.org/0000-0002-3183-4118, Qiuji Ye https://orcid.org/0000-0002-3812-3001, Feng Li https://orcid.org/0000-0002-9680-4614, Murugesan Palaniappan https://orcid.org/0000-0003-4916-6565, Zhi Tan, Fei Yuan, Chad J. Creighton, A dog Tang, Ramya P. massaging, Xiaoming Guan, Damian W. Younger, Diana Monsivais and Martin M. Matzuk https://orcid.org/0000-0002-1445-8632 Authors Files & AffiliationsContributed by Martin M. Matzuk; got December 28, 2023; current March 22, 2024; reviewed by Thomas D. Chung and Yikai WangMay likely perhaps 3, 2024121 (19) e2322934121SignificanceEPH receptors (EPHs) are extremely sought-after drug targets owing to their mandatory roles in affirming acceptable mobile functions in each and every physiological and disease circumstances. On the opposite hand, miniature potency and specificity pose most necessary boundaries to the event of tiny-molecule inhibitors for EPHs. Here, using excessive-throughput DNA-encoded...
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