A DNA language model based on multispecies alignment predicts the effects of genome-wide variants
Science & Technology

A DNA language model based on multispecies alignment predicts the effects of genome-wide variants

Goldfeder, R. L., Wall, D. P., Khoury, M. J., Ioannidis, J. P. & Ashley, E. A. Human genome sequencing at the population scale: a primer on high-throughput DNA sequencing and analysis. Am. J. Epidemiol. 1861000–1009 (2017). Article  PubMed  PubMed Central  Google Scholar Marwaha, S., Knowles, J. W. & Ashley, E. A. A guide for the diagnosis of rare and undiagnosed disease: beyond the exome. Genome Med. 1423 (2022).Lee, S., Abecasis, G. R., Boehnke, M. & Lin, X. Rare-variant association analysis: study designs and statistical tests. Am. J. Hum. Genet. 955–23 (2014). Article  ...
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New Theoretical Model Calculates Chances of Intelligent Life in Our Universe and Beyond
Top Stories

New Theoretical Model Calculates Chances of Intelligent Life in Our Universe and Beyond

Top Stories Tamfitronics In 1961, American astrophysicist and astrobiologist Dr. Frank Drake devised an equation in which several factors are multiplied together to estimate the number of intelligent civilizations in our Milky Way Galaxy capable of making their presence known to humans. More than 60 years on, astrophysicists have produced a different model which instead focuses on the conditions created by the acceleration of the Universe’s expansion and the amount of stars formed. It is thought this expansion is being driven by dark energy that makes up more than two thirds of the Universe.Artistic impression of a Multiverse. Image credit: Jaime Salcido / EAGLE Collaboration.“Understanding dark energy and the impact on our Universe is one of the biggest challenges in cosmology and fundamental physics,” said Dr. Daniele Sorini, a researcher at Durham University’s Institute for...
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Former Model Who Quit ‘Party-Girl’ Life in L.A. to Live In an Off-Grid Bus With Her Baby Says She’s Saving Thousands in Rent—and Is Happier Than Ever
Lifestyle

Former Model Who Quit ‘Party-Girl’ Life in L.A. to Live In an Off-Grid Bus With Her Baby Says She’s Saving Thousands in Rent—and Is Happier Than Ever

Lifestyle As you were browsing, something about your browser made us think you might be a bot. There are a few reasons this might happen, including: You're a power user moving through this website with super-human speed You've disabled JavaScript and/or cookies in your web browser A third-party browser plugin is preventing JavaScript from running. ...
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NASA unveils model of LISA, a satellite array for studying ripples in space-time
Science & Technology

NASA unveils model of LISA, a satellite array for studying ripples in space-time

NASA Space Technology The prototype LISA telescope undergoes post-delivery inspection in a darkened NASA Goddard clean room on May 20. The entire telescope is made from an amber-colored glass-ceramic that resists changes in shape over a wide temperature range, and the mirror’s surface is coated in gold. Credit: NASA / Dennis HenryNASA has released new images of the full-scale prototypes of six telescopes slated to observe some of the universe’s tiniest fluctuations. On October 22, the agency showed off mock-ups of the Laser Interferometer Space Antenna (LISA), a European Space Agency-led project slated to embark on its mission around 2035. While not the final working equipment meant to measure gravitational waves, the mock-up offers glimpses of a design that will likely resemble the machine array destined to help astronomers discover potentially groundbreaking insights into the...
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