Tag Archives: Identification
Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation
Technology tamfitronics Data availability WES and RNA-seq data from the training HCT, DFCI-MRD and HP-MRD cohorts is available through the dbGaP portal (accession phs003394.v1.p1). The original mass spectra, PSMs and protein sequence databases used for searches have been deposited in the public proteomics repository MassIVE (https://massive.ucsd.edu) and are accessible at ftp://massive.ucsd.edu/v08/MSV000095025/. Original mass spectrometry data for the previously published B721.221 monoallelic immunopeptidomes are accessible at ftp://massive.ucsd.edu/MSV000080527. The GI GvHD scRNA-seq dataset is available from the corresponding author upon reasonable request. All external datasets used in this study (identified by reference number) are summarized in Supplementary Fig....
Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology
Technology tamfitronics Chandrashekhar Madasu, in cyan Liao https://orcid.org/0000-0002-7198-2182, Sydney E. Parks, Kiran L. Sharma https://orcid.org/0000-0002-1988-389X, Kurt M. Drill https://orcid.org/0000-0002-3183-4118, Qiuji Ye https://orcid.org/0000-0002-3812-3001, Feng Li https://orcid.org/0000-0002-9680-4614, Murugesan Palaniappan https://orcid.org/0000-0003-4916-6565, Zhi Tan, Fei Yuan, Chad J. Creighton, A dog Tang, Ramya P. massaging, Xiaoming Guan, Damian W. Younger, Diana Monsivais and Martin M. Matzuk https://orcid.org/0000-0002-1445-8632 Authors Files & AffiliationsContributed by Martin M. Matzuk; got December 28, 2023; current March 22, 2024; reviewed by Thomas D. Chung and Yikai WangMay likely perhaps 3, 2024121 (19) e2322934121SignificanceEPH receptors (EPHs) are extremely sought-after drug targets owing to their mandatory roles in affirming acceptable mobile functions in each and every physiological and disease circumstances. On the opposite hand, miniature potency and specificity pose most necessary boundaries to the event of tiny-molecule inhibitors for EPHs. Here, using excessive-throughput DNA-encoded...
Identification of clinically connected T cell receptors for personalized T cell remedy the usage of combinatorial algorithms
Technology tamfitronics MajorAdoptive cell switch (ACT) of tumor-infiltrating lymphocytes (TILs) is a personalised immunotherapy potential with demonstrated superiority over second-line checkpoint blockade immunotherapy in patients with melanoma1,2. Recent be taught show that the frequency of tumor-reactive T cells (TRTs) in melanoma tumors ancient to amplify TILs, and their quantity in cognate TIL merchandise infused to patients are valuable determinants of TIL ACT efficacy3,4. Furthermore, it has been hypothesized that the paucity of TRTs in a form of solid tumors can show the lower success charge of TIL remedy in these patients5. Alternatively, the usage of TCR-engineered T cells has confirmed promise for treating solid tumors6. Nonetheless, when personalized, this potential faces the pain of including...
