Decrypting the molecular foundation of cell drug phenotypes by dose-resolved expression proteomics
Technology tamfitronics PredominantMost tablets act on proteins1,2 and it has been known since the times of Paracelsus that tablets exert their effects in a dose-dependent model. The molecular processes main to a drug-prompted replace in cell phenotype can even be roughly divided into (1) aim binding, (2) pathway engagement and (3) cell reprogramming to strategy at a brand new viable instruct or cell loss of life, together forming the MoA of a drug2,3. This day, quantitative mass spectrometry is the most comprehensive ability for the proteome-extensive characterization of medication on all three ranges attributable to of its skill to assay thousands of proteins in complex cell backgrounds in parallel2. The technology does...
