Integrated epigenetic and genetic programming of primary human T cells
Science & Technology

Integrated epigenetic and genetic programming of primary human T cells

MainEngineered T cells, containing transgenic T cell receptors (TCRs), chimeric antigen receptors (CARs) or other synthetic antigen receptors, are an emerging modality to treat cancer, autoimmunity and infectious diseases1,2,3,4. Although autologous CAR-T cells have been transformative for treating aggressive hematological malignancies, substantial advances are needed to achieve similar success in treating solid tumors and generating allogeneic cell therapies. Solid tumors demonstrate a number of challenges including immunosuppressive tumor microenvironments, physical barriers and T cell exhaustion that limit the responses of current therapies5,6,7. Allogeneic CAR-T cells must additionally overcome T cell rejection...
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Is a Vibration Plate the Ultimate Weight Loss Hack? We Consulted the Pros
Science & Technology

Is a Vibration Plate the Ultimate Weight Loss Hack? We Consulted the Pros

You've seen them online, and let's be honest, the promise is almost offensively tempting: stand on a vibrating plate and... get fit? The claims that these machines can help you lose weight and build strength with minimal effort sound way too good to be true. So, is this a revolutionary piece of exercise equipment or just an expensive gimmick destined to become a laundry rack? Can you really just shake your way to a better body? We got tired of wondering, so we went straight to the fitness experts to get the real answers on the benefits, the risks, and who should absolutely step away from the wobble.Don't miss any of our unbiased tech content and lab-based reviews. Add CNET as a preferred Google source on Chrome.What is a vibration plate?Whole-body vibration plates are a form of exercise...
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Who should I start Week 7? Fantasy Sunday London start sit lineup decisions, inactives, breaking news
Breaking News

Who should I start Week 7? Fantasy Sunday London start sit lineup decisions, inactives, breaking news

JUMP TO:Who to start today in fantasy Week 7NFL Fantasy Inactives for Week 7Fantasy Live News to Know for Week 7 SundayWeek 7 rankingsNFL Fantasy Weather tipsEvery weekend during the NFL season, fantasy football players must stay on top of the latest news. This especially matters on Sundays, when the league releases the injury and inactive reports for every game. Below, you'll find Week 7 start-sit lineup recommendations to help you make early decisions on who to start in your fantasy league. Now that you've set your lineups with players from the 9:30 a.m. ET London game between the Los Angeles Rams and Jacksonville Jaguars, let's fill out the rest of...
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