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Integrated epigenetic and genetic programming of primary human T cells
MainEngineered T cells, containing transgenic T cell receptors (TCRs), chimeric antigen receptors (CARs) or other synthetic antigen receptors, are an emerging modality to treat cancer, autoimmunity and infectious diseases1,2,3,4. Although autologous CAR-T cells have been transformative for treating aggressive hematological malignancies, substantial advances are needed to achieve similar success in treating solid tumors and generating allogeneic cell therapies. Solid tumors demonstrate a number of challenges including immunosuppressive tumor microenvironments, physical barriers and T cell exhaustion that limit the responses of current therapies5,6,7. Allogeneic CAR-T cells must additionally overcome T cell rejection by the host immune system and toxicities such as graft-versus-host disease8. A number of studies have nominated genes that, in principle, can be manipulated to overcome these challenges; however, enacting these strategies in cell products remains a major challenge and will require clinically relevant,...
Is a Vibration Plate the Ultimate Weight Loss Hack? We Consulted the Pros
You've seen them online, and let's be honest, the promise is almost offensively tempting: stand on a vibrating plate and... get fit? The claims that these machines can help you lose weight and build strength with minimal effort sound way too good to be true.
So, is this a revolutionary piece of exercise equipment or just an expensive gimmick destined to become a laundry rack? Can you really just shake your way to a better body? We got tired of wondering, so we went straight to the fitness experts to get the real answers on the benefits, the risks, and who should absolutely step away from the wobble.Don't miss any of our unbiased tech content and lab-based reviews. Add CNET as a preferred Google source on Chrome.What is a vibration plate?Whole-body vibration plates are a form of exercise...
H-1B vs K Visa: Two visions for foreign talent -1B?
H-1B vs K Visa: As governments across the world tighten their immigration policies or recalibrate them for economic advantage, global skilled workers are increasingly being forced to choose between shifting priorities, and now, the US and China, two of the world's largest economies, are both reshaping how they attract foreign talent. But they’re moving in very different directions.US Increases H-1B Visa Fee to $100,000In the US, the H-1B visa, which was long seen as a gateway for skilled professionals, especially in tech, is facing a major upheaval, as per a report. What Is the H-1B Visa and Who Uses It?H-1B visas allow highly skilled foreign professionals to work in speciality occupations in the US that generally require at least a bachelor’s degree to fulfil the role for jobs in the fields of science, technology, engineering...
Long-read sequencing and chemical synthesis access previously hidden antibiotics
Research Briefing Published: 23 September 2025 ...
The mysterious marble head found in Crimea belonged to a woman who weighed on the fate of her city
In 2003, an exhumed marble head in Crimea intrigued archaeologists. Twenty years later, an investigation mixing science and art history lifts the veil on the identity of this female figure which marked the history of its city.
In 2003, the excavations of the ancient Greek city of Tauric dear, the current Sébastopol in Crimea, delivered the head marblemarble of a Roman matron, remarkably preserved in the half-sous-ground of a large residence of 718 m², close to the theater and the Agora. Around it, currencies, pottery and an altar in ceramicceramic With the effigy of Artemis and Apollo attests to an intact archaeological context, allowing a fine dating: the piece was deposited between 60 and 240 AD, probably at the end of the IIᵉ.
Although damaged (neznez and broken facial features before its burial) the sculpture retains remarkable...
Pest Resistance Threatens New Biotech Corn Defense | Mirage News
Corn rootworms, pests responsible for billions of dollars in yearly crop losses, are evolving resistance that weakens even the latest biotechnology controls, according to a new study published in the journal Proceedings of the National Academy of Sciences.
Drawing on decades of data across multiple states, University of Arizona entomologists found that field-evolved resistance to Bacillus thuringiensis, or Bt, is undermining the effectiveness of corn that targets rootworms with the combination of Bt and RNA interference, or RNAi, a new biotech control that turns the rootworms' own genetic instructions against them.
The research team analyzed extensive field data collected over the past two decades in 12 previous studies, including millions of rootworms evaluated across the Corn Belt, which extends from western Ohio to eastern Nebraska and northeastern Kansas.
"The results consistently show that in fields where...
NASA ISRO radar satellite beams first Earth images from space
NASA ISRO radar satellite beams first Earth images from spaceby Clarence OxfordLos Angeles CA (SPX) Sep 26, 2025Preliminary radar images from the NASA-ISRO Synthetic Aperture Radar (NISAR) mission reveal the extraordinary capabilities of the most advanced Earth-observing radar satellite ever launched. The spacecraft, developed through a long-standing U.S.-India partnership, is now preparing for full science operations later this year.
Launched by ISRO on July 30, NISAR is designed to provide unprecedented insights into natural hazards, agriculture, and climate change. Its first L-band synthetic aperture radar images, released in August, captured detailed views of Mount Desert Island in Maine and agricultural regions of North Dakota. Waterways, forests, farmland, and human structures were all distinctly visible, underscoring the system's ability to differentiate between land cover types.
"The successful capture of these first images from NISAR is a remarkable example...
The Great Flip: How Gen Z is quietly turning rural India into country’s new startup capital
INDIA
India’s most powerful startup revolution is no longer happening in glass towers or tech parks. It’s happening in villages, small towns, and district headquarters driven by a hyper-digital, deeply rooted Gen Z that’s creating jobs, building technology, and transforming the Indian economy. Shashank
Updated : Sep 27, 2025, 06:46 PM IST The Great Flip: How Gen Z is quietly turning rural India into country’s new startup capitalAdd DNA as a Preferred SourceTRENDING NOW US official issues BIG clarification on new USD 100,000 H-1B rules, says, 'Visa fee applies only to...' Donald Trump administration set to make another BIG announcement on..., US President says,' we can't let people...' Bad news for Indian Amazon employees? Jeff Bezos' company issues statement as Trump slaps $100,000 fee on H-1B visas PM...
6 fun photos to celebrate Sea Otter Awareness week
The United States is home to two species of sea otters that float on the ocean in groups called rafts.Image: Linda Dron.
Get the Popular Science daily newsletter💡 Breakthroughs, discoveries, and DIY tips sent every weekday.Despite almost being hunted to the brink of extinction, sea otters in the United States are seeing an important recovery. Sea Otter Awareness Week offers us another opportunity to learn more, and let’s be honest, look at pictures and videos of these furry mammals. This year’s theme is Anchored in Hope, in honor of the spirit of recovery and connectedness between sea otters, their ecosystem, and humans. The way that sea otters wrap themselves in kelp when the water gets rough, people can anchor themselves in hope for future ocean conservation work.
Enjoy these images from Sea Otter Savvy, a community...
Fujitsu and AIST sign collaboration agreement to strengthen international industrial competitiveness in quantum technology
Fujitsu and AIST sign collaboration agreement to strengthen international industrial competitiveness in quantum technology
Kawasaki and Tsukuba, Japan, September 29, 2025 - (JCN Newswire) - Fujitsu Limited and the Global Research and Development Center for Business by Quantum-AI technology (G-QuAT) at the National Institute of Advanced Industrial Science and Technology (AIST) today announced the signing of a collaboration agreement to strengthen international industrial competitiveness in quantum technology. The agreement, signed on September 26, 2025, aims to enhance cooperation between the two organizations, thereby boosting Japan's standing globally in this sector.
As part of the agreement, Fujitsu and G-QuAT will leverage their combined resources, including quantum computer-related technologies, manufacturing and evaluation facilities, and will promote research and development and personnel exchange. In this way, the partnership aims to foster international collaboration and research cooperation, ultimately contributing to sustainable...
Webb Discovers Exomoon-Forming Circumplanetary Disk around Gas-Giant Exoplanet
Astronomers using the NASA/ESA/CSA James Webb Space Telescope have found the carbon-rich disk surrounding CT Cha b, a giant exoplanet around 620 light-years away from Earth in the constellation of Chamaeleon. Their results provide the first direct insight into the chemical and physical properties of material being accreted onto a gas giant and into its potential moon system.An artistic rendering of a dust and gas disk encircling the young exoplanet CT Cha b. Image credit: NASA / ESA / CSA / STScI / G. Cugno, University of Zürich & NCCR PlanetS / S. Grant, Carnegie Institution for Science / J. Olmsted, STScI / L. Hustak, STScI.CT Cha, also known as PDS 44 and TIC 454259409, is only 2 million years old and still accreting circumstellar material.
However, the circumplanetary disk discovered by Webb is not part...
Derivation of embryonic stem cells across avian species
MainAvians, especially chickens, are crucial model organisms in developmental biology, virology, immunology, epigenetics, conservation biology and genomics related to domestication1,2,3. Moreover, the chicken model organism has enhanced our understanding of human diseases4. However, due to the lack of genetic tools in avians, the use of this species in research has been greatly limited.
Embryonic stem (ES) cells derived from mice and rats can be maintained in culture indefinitely while retaining the ability to contribute to chimera formation and transmit through the germline5,6,7,8. This property has enabled us to generate numerous genetically modified animals, substantially advancing our understanding of biology in various aspects. However, attempts to establish chimeric and germline-competent ES cell lines from species other than rodents have, thus far, proved unsuccessful.
Blastodermal cells isolated from freshly laid chicken eggs (EGK.X stage) can contribute to both somatic...
